Combination therapy with extra-mild hypothermia
نویسندگان
چکیده
منابع مشابه
Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia.
BACKGROUND AND PURPOSE Hypothermia has been suggested to be the most potent therapeutic approach to reduce experimental ischemic brain injury identified to date, and mild hypothermia is increasingly used for neuroprotection during neurovascular surgery. We have recently demonstrated that combined administration of tirilazad mesylate and magnesium provides for an overall enhanced neuroprotective...
متن کاملCombination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats.
BACKGROUND AND PURPOSE We have recently demonstrated that pretreatment with magnesium (calcium and glutamate antagonist) and tirilazad (antioxidant) in combination with intraischemic mild hypothermia (33 degrees C) (MTH) offers superior neuroprotective efficacy in a rat model of focal transient cerebral ischemia. In the present study, we investigated the time window of this treatment strategy w...
متن کاملNeuroprotection in transient focal cerebral ischemia by combination drug therapy and mild hypothermia: comparison with customary therapeutic regimen.
BACKGROUND AND PURPOSE A combined therapeutic approach has been advocated repeatedly for treatment of focal cerebral ischemia. A clinical example of combined therapy is administration of nimodipine, mannitol, dexamethasone, and barbiturates during temporary occlusion of a cerebral artery in neurovascular surgery. We have recently demonstrated outstanding neuroprotective properties of a combinat...
متن کاملDelayed combination therapy of local brain hypothermia and decompressive craniectomy on acute stroke outcome in rat
Objective(s):Hypothermia and decompressive craniectomy (DC) have been shown to be neuroprotective. This study was designed to evaluate neuroprotective effects of delayed singular or combination of DC and local hypothermia on stroke. Materials and Methods: Cerebral ischemia was induced in 48 Wistar rats assigned to 4 groups: control, decompressive craniectomy (DC), local hypothermia (LH), combin...
متن کاملSPOTLIGHT REVIEW Myocardial protection with mild hypothermia
Mild hypothermia, 32–358C, is very potent at reducing myocardial infarct size in rabbits, dogs, sheep, pigs, and rats. The benefit is directly related to reduction in normothermic ischaemic time, supporting the relevance of early and rapid cooling. The cardioprotective effect of mild hypothermia is not limited to its recognized reduction of infarct size, but also results in conservation of post...
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ژورنال
عنوان ژورنال: Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)
سال: 2015
ISSN: 0915-9401,2188-7519
DOI: 10.16977/cbfm.26.2_83